Azetidine hydrochloride → HCID 90449826, compound

HRID 1411300Notes

Reaction equation

[C:1]([N:4]1[CH2:8][CH2:7][C:6]2([C:16]3[C:11](=[CH:12][CH:13]=[C:14](/[CH:17]=[CH:18]/[C:19](O)=[O:20])[CH:15]=3)[N:10]([C:22](=[O:30])[NH:23][C:24]3[S:25][C:26]([Cl:29])=[CH:27][N:28]=3)[CH2:9]2)[CH2:5]1)(=[O:3])[CH3:2].Cl.[NH:32]1[CH2:35][CH2:34][CH2:33]1>>[C:1]([N:4]1[CH2:8][CH2:7][C:6]2([C:16]3[C:11](=[CH:12][CH:13]=[C:14](/[CH:17]=[CH:18]/[C:19]([N:32]4[CH2:35][CH2:34][CH2:33]4)=[O:20])[CH:15]=3)[N:10]([C:22]([NH:23][C:24]3[S:25][C:26]([Cl:29])=[CH:27][N:28]=3)=[O:30])[CH2:9]2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 12308726Azetidine hydrochloride

HCID 90449483HCID 90449483, compound

Product 1

HCID 90449826HCID 90449826, compound

Procedure

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Example 85, with the exceptions that (E)-3-(1′-acetyl-1-((5-chlorothiazol-2-yl)carbamoyl)spiro[indoline-3,3′-pyrrolidin]-5-yl)acrylic acid was used instead of 2-(5-chloro-1′-(methoxycarbonyl)spiro[indoline-3,3′-pyrrolidin]-1-ylcarboxamido)thiazole-4-carboxylic acid, and that azetidine hydrochloride was used instead of dimethylamine hydrochloride.

Workup

customThe captioned compound was obtained in the form of a white solid

Sources & evidence

ORD record: ord-b151e3be51434faba95a83dab252a88c
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921576B2

Reaction notes

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