Acetoxyacetyl chloride → 5-(3-(azetidin-1-yl)-3-oxopropyl)-1'-(2-hydroxyacetyl)-N-(5-methoxythiazol-2-yl)spiro[indoline-3,3'-pyrrolidine]-1-carboxamide

Participants

Reaction Steps

The captioned compound was obtained in the form of a white solid by performing the same reactions and/or treatments as those in Step 5 of Example 383, and Examples 1, 2, 3, 29, and 85, with the exceptions that the 1-(2-(trimethylsilyl)ethyl) 1′-tert-butyl 5-(3-ethoxy-3-oxopropyl)spiro[indoline-3,3′-pyrrolidine]-1,1′-dicarboxylate obtained in Step 1 of Example 412 was used instead of 1-(2-(trimethylsilyl)ethyl) 1′-tert-butyl 5-(methylsulfonyl)spiro[indoline-3,3′-pyrrolidine]-1,1′-dicarboxylate, that 2-amino-5-methoxythiazole was used instead of 2-amino-5-chlorothiazole hydrochloride, that acetoxyacetyl chloride was used instead of acetyl chloride, and that azetidine hydrochloride was used instead of dimethylamine hydrochloride.

Provenance & Evidence