反应详情

温度

110 °C

A sealed tube equipped with a magnetic stirrer was charged with (R)-3-(4-aminophenyl)-1,4-dimethylpiperazin-2-one (1.08 g, 5 mmol), 3,5-dibromo-1-methylpyridin-2(1H)-one (1.47 g, 5.5 mmol), diisopropylethylamine (1.94 g, 15 mmol), and iPrOH (20 mL). After three cycles of vacuum/argon flush, the mixture was heated at 110° C. overnight. After cooling down to room temperature, water (20 mL) was added to, and the mixture was extracted with ethyl acetate (50 mL×2). The organic layer was separated, combined, dried over anhydrous sodium sulfate, and concentrated. The resulting residue was purified by silica gel column chromatography eluting with dichloromethane/methanol (10:1, UV) to afford 114a (1.8 g, 90%) as a red solid. LCMS: [M+H]+ 406

1. customA sealed tube equipped with a magnetic stirrer
2. customAfter three cycles of vacuum/argon flush
3. temperatureAfter cooling down to room temperature
4. additionwater (20 mL) was added to, and the mixture
5. extractionwas extracted with ethyl acetate (50 mL×2)
6. customThe organic layer was separated
7. dry with materialdried over anhydrous sodium sulfate
8. concentrationconcentrated
9. customThe resulting residue was purified by silica gel column chromatography
10. washeluting with dichloromethane/methanol (10:1, UV)