反应详情

温度

30 °C

A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer was charged with (3-nitro-1H-pyrazol-5-yl)methanol (0.57 g, 4.0 mmol), Cs2CO3 (261 mg, 0.8 mmol), and 2-methyloxirane (20 mL). The mixture was stirred at 30° C. for 2 days. The mixture was cooled to room temperature and diluted with dichloromethane (100 mL). The resulting mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica-gel column chromatography eluting with 30:1 dichloromethane/methanol to afford 250a (0.40 g, 50%) as a white solid. MS-ESI: [M+H]+ 202.3

1. customA 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer
2. temperatureThe mixture was cooled to room temperature
3. filtrationThe resulting mixture was filtered
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe residue was purified by silica-gel column chromatography
6. washeluting with 30:1 dichloromethane/methanol