HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1412045Generated: November 2, 2026
Potassium Carbonate → 5-(2-Methoxyethyl)-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine
https://huagongshe.com/reaction/1412045
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromoethyl methyl ether | HCID 80972 | — |
| Reactant | 5-bromo-1-methyl-3-(5-(oxetan-3-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-ylamino)pyridin-2(1H)-one | HCID 58044169 | — |
| Reactant | 2-Nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine | HCID 58044279 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 5-(2-Methoxyethyl)-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine | HCID 86683990 | — |
Reaction Steps
To a solution of 2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine (190 mg, 1.13 mmol) 125i in acetonitrile (10 mL) was added K2CO3 (311.9 mg, 2.26 mmol) and 1-bromo-2-methoxyethane (188.3 mg, 1.36 mmol). The reaction mixture was heated at 80° C. for 17 h under microwave irradiation. Analysis of reaction mixture by LCMS showed complete conversion to the desired product. The mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure to afford 304a as a white solid (230 mg, 90%), which was used in the next step without further purification. MS-ESI: [M+H]+ 227.0
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08921353B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-d62b0e544d214b50be523f8579c9fdea |
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| Source note | uspto-grants-2014_12 |
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