反应详情

温度

50 °C

To a solution of 307a (crude, 2.5 mmol) in ethanol (95%, 30 mL) was added NH2NH2 water (1.25 g, 25.0 mmol), Pd/C (100 mg) under nitrogen protection. The mixture was stirred at 50° C. for 1.5 h. It was then cooled to room temperature and filtered through a pad of CELITE®. The filtrate was concentrated under reduced pressure and the residue was recrystallized from anhydrous ethanol (5 mL) to afford 307b as white solid (340 mg, 84% over two steps). MS-ESI: [M+H] 162.3

1. temperatureIt was then cooled to room temperature
2. filtrationfiltered through a pad of CELITE®
3. concentrationThe filtrate was concentrated under reduced pressure
4. customthe residue was recrystallized from anhydrous ethanol (5 mL)