3,5-Dibromo-1-methylpyridin-2(1H)-one → HCID 86684615, compound

HRID 1412129Notes

Reaction equation

HRID 1412129 reaction equation
[NH2:1][C:2]1[CH:14]=[C:5]2[CH2:6][N:7]([CH2:10][CH2:11][C:12]#[N:13])[CH2:8][CH2:9][N:4]2[N:3]=1.Br[C:16]1[C:17](=[O:24])[N:18]([CH3:23])[CH:19]=[C:20]([Br:22])[CH:21]=1>>[Br:22][C:20]1[CH:21]=[C:16]([NH:1][C:2]2[CH:14]=[C:5]3[CH2:6][N:7]([CH2:10][CH2:11][C:12]#[N:13])[CH2:8][CH2:9][N:4]3[N:3]=2)[C:17](=[O:24])[N:18]([CH3:23])[CH:19]=1

Participants

3

Reactant 2

HCID 36143503,5-Dibromo-1-methylpyridin-2(1H)-oneHCID 866846163-(2-Amino-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)propanenitrile

Product 1

HCID 86684615HCID 86684615, compoundYield 63.1%

Procedure

Following the procedure of Example 309c, and starting with 338b (120 mg, 0.63 mmol) and 3,5-dibromo-1-methylpyridin-2(1H)-one (169 mg, 0.63 mmol) afforded 338c as a yellow solid (150 mg, 63%). MS-ESI: [M+H]+ 377.2

Sources & evidence

ORD record
ord-09208c565ace4262b198a8f36c9318d6
Source dataset
uspto-grants-2014_12
Patent number
US08921353B2

Reaction notes

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