反应详情

5-Chloro-2-methylthio-4-pyrimidine carboxylic acid (30 g) was heated at 180°-200° C. until all the solid had melted and the evolution of carbon dioxide had ceased (5 min). The residue was allowed to cool and then washed with several portions of chloroform. The chloroform washings were filtered to remove dark insoluble material and the filtrate was concentrated to give 5-chloro-2-methylthiopyrimidine as a pale brown crystalline solid (21 g, 89%), m.p. 55° C.

1. custom(5 min)
2. temperatureto cool
3. washwashed with several portions of chloroform
4. filtrationThe chloroform washings were filtered
5. customto remove dark insoluble material
6. concentrationthe filtrate was concentrated