Boron tribromide → HCID 12800895, compound

Participants

Reaction Conditions

Reaction Steps

5-Chloro-2-(4-methoxyphenylthio)pyrimidine (7.5 g) was dissolved in methylene chloride (60 ml) and the solution was cooled to -78° C. Boron tribromide (18 g) was added dropwise to the stirred solution, the temperature of the solution being maintained at -65° to -75° C. On completion of the addition the reaction mixture was stirred for a further one hour at -78° C. and then the temperature of the reaction mixture was allowed to rise slowly to 20° C. The reaction was quenched with water (50 ml), the resultant suspension cooled and filtered to give 4-(5-chloro-2-pyrimidylthio)phenol (5 g) as an almost colourless solid.

Provenance & Evidence