Methyl(6-phenoxy-2-pyridyl)methanol → HCID 54189122, compound

HRID 1413098Notes

Reaction equation

HRID 1413098 reaction equation
[CH3:1][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:5]=1)[OH:3].[CH3:17][CH:18]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[N:21]=1)[OH:19].[F:34][C:35]1[CH:40]=[CH:39][C:38]([CH:41]=[CH:42][CH:43]([CH:47]([CH3:49])[CH3:48])[C:44](O)=[O:45])=[CH:37][CH:36]=1>>[F:34][C:35]1[CH:36]=[CH:37][C:38]([CH:41]=[CH:42][CH:43]([CH:47]([CH3:49])[CH3:48])[C:44]([O:3][CH:2]([CH3:1])[C:4]2[CH:9]=[CH:8][CH:7]=[C:6]([O:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:5]=2)=[O:45])=[CH:39][CH:40]=1.[F:34][C:35]1[CH:36]=[CH:37][C:38]([CH:41]=[CH:42][CH:43]([CH:47]([CH3:49])[CH3:48])[C:44]([O:19][CH:18]([CH3:17])[C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)[N:21]=2)=[O:45])=[CH:39][CH:40]=1

Participants

5

Reactant 3

HCID 12850226Methyl(6-phenoxy-2-pyridyl)methanolHCID 20293459Methyl[6-(4-fluorophenoxy)-2-pyridyl]methanolHCID 538855142-Isopropyl-4-(4-fluorophenyl)-3-butenoic acid

Product 2

HCID 54189122HCID 54189122, compoundHCID 54316819HCID 54316819, compound

Procedure

Following the procedure of Example 3, each of methyl(6-phenoxy-2-pyridyl)methanol and methyl[6-(4-fluorophenoxy)-2-pyridyl]methanol is reacted with 4-(4-fluorophenyl)-2-isopropyl-3-butenoic acid to yield methyl(6-phenoxy-2-pyridyl)methyl 4-(4-fluorophenyl)-2-isopropyl-3-butenoate and methyl[6-(4-fluorophenoxy)-2-pyridyl]methyl 4-(4-fluorophenyl)-2-isopropyl-3-butenoate, respectively.

Sources & evidence

ORD record
ord-1085acdaf7d7427c8eed35abbf73a2e1
Source dataset
uspto-grants-1981_02
Patent number
US04248875

Reaction notes

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