(6-Benzoyl-2-pyridyl)methanol → (6-Benzoyl-2-pyridyl)methyl 4-(4-chlorophenyl)-2-isopropyl-3-butenoate

HRID 1413099Notes

Reaction equation

HRID 1413099 reaction equation
[C:1]([C:9]1[N:14]=[C:13]([CH2:15][OH:16])[CH:12]=[CH:11][CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([CH:24]=[CH:25][CH:26]([CH:30]([CH3:32])[CH3:31])[C:27](O)=[O:28])=[CH:20][CH:19]=1.[F:33][C:34]1[CH:39]=[CH:38][C:37]([CH:40]=[CH:41][CH:42]([CH:46]([CH3:48])[CH3:47])[C:43]([OH:45])=[O:44])=[CH:36][CH:35]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([CH:24]=[CH:25][CH:26]([CH:30]([CH3:32])[CH3:31])[C:27]([O:16][CH2:15][C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([C:1](=[O:8])[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[N:14]=2)=[O:28])=[CH:22][CH:23]=1.[F:33][C:34]1[CH:35]=[CH:36][C:37]([CH:40]=[CH:41][CH:42]([CH:46]([CH3:48])[CH3:47])[C:43]([O:45][CH2:15][C:13]2[CH:12]=[CH:11][CH:10]=[C:9]([C:1](=[O:8])[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[N:14]=2)=[O:44])=[CH:38][CH:39]=1

Participants

5

Reactant 3

HCID 20293448(6-Benzoyl-2-pyridyl)methanolHCID 538855142-Isopropyl-4-(4-fluorophenyl)-3-butenoic acidHCID 541367594-(4-Chlorophenyl)-2-isopropyl-3-butenoic acid

Product 2

HCID 54313312(6-Benzoyl-2-pyridyl)methyl 4-(4-chlorophenyl)-2-isopropyl-3-butenoateHCID 57069556(6-Benzoyl-2-pyridyl)methyl 4-(4-fluorophenyl)-2-isopropyl-3-butenoate

Procedure

The compounds (6-benzoyl-2-pyridyl)methanol is reacted with 4-(4-chlorophenyl)-2-isopropyl-3-butenoic acid or 4-(4-fluorophenyl)-2-isopropyl-3-butenoic acid, following the procedure of Example 3, to give (6-benzoyl-2-pyridyl)methyl 4-(4-chlorophenyl)-2-isopropyl-3-butenoate or (6-benzoyl-2-pyridyl)methyl 4-(4-fluorophenyl)-2-isopropyl-3-butenoate. (6-Benzoyl-2-pyridyl)methanol is prepared as described in my application Ser. No. 069,446, filed on or about Aug. 24, 1979.

Sources & evidence

ORD record
ord-93d0b6c09d854b6e956fced2a16d9c9f
Source dataset
uspto-grants-1981_02
Patent number
US04248875

Reaction notes

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