Water → 2-[(2-pyridylmethyl)thio]-1H-naphth[2,3-d]imidazole

HRID 1413107Notes

Reaction equation

HRID 1413107 reaction equation
[CH3:1][S:2][C:3]1[NH:7][C:6]2[CH:8]=[C:9]3[C:14](=[CH:15][C:5]=2[N:4]=1)[CH:13]=[CH:12][CH:11]=[CH:10]3.SC[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1.O>C(O)C>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[CH2:1][S:2][C:3]1[NH:4][C:5]2[CH:15]=[C:14]3[C:9](=[CH:8][C:6]=2[N:7]=1)[CH:10]=[CH:11][CH:12]=[CH:13]3

Participants

5

Reactant 3

HCID 962WaterHCID 2560712-PyridinemethanethiolHCID 128720792-(methylthio)-1H-naphtho[2,3-d]imidazole

Product 1

HCID 223941842-[(2-pyridylmethyl)thio]-1H-naphth[2,3-d]imidazoleYield 81.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.45 g of 2-methylthio-1H-naphth[2,3-d]imidazole and 0.65 g of 2-mercaptomethylpyridine were heated for 40 hours under reflux in 10 ml of ethanol. 10 ml of water were added to the homogeneous solution and the precipitate formed was filtered off. 0.50 g of 2-[(2-pyridylmethyl)thio]-1H-naphth[2,3-d]imidazole having a m.p. of 170° was obtained.

Workup

  1. customthe precipitate formed
  2. filtrationwas filtered off

Sources & evidence

ORD record
ord-912ef9e4fffc48e484a28a9f07d219fa
Source dataset
uspto-grants-1981_02
Patent number
US04248880

Reaction notes

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