Phenethyl bromide → HCID 20293505, compound

HRID 1413117Notes

Reaction equation

HRID 1413117 reaction equation
[CH3:1][N:2]([CH3:14])[C:3](=[O:13])[CH:4]([C:6]1([OH:12])[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH3:5].[CH2:15](Br)[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(O)C>[OH:12][C:6]1([CH:4]([CH3:5])[C:3]([N:2]([CH3:1])[CH3:14])=[O:13])[CH2:7][CH2:8][N:9]([CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 7666Phenethyl bromideHCID 20383018HCID 20383018, compound

Product 1

HCID 20293505HCID 20293505, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(4-hydroxy-4-piperidyl)propionic acid N,N-dimethylamide and phenethyl bromide are reacted in a manner analogous to that described in Example 3. The resulting crude title compound is dissolved in ethanol, the calculated amount of fumaric acid is added and subsequently ether is added until the solution becomes turbid. The resulting hydrogen fumarate form of the title compound has a M.P. of 188°-189° after recrystallization from ethanol/ether.

Sources & evidence

ORD record
ord-89c9cc6970c04833aae691b30499cb84
Source dataset
uspto-grants-1981_02
Patent number
US04248877

Reaction notes

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