HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 7-Methylsulfamoyl-1,4-benzodioxane-5-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,3-Dihydro-7-(N-methylsulphamoyl)-1,4-benzodioxin-5-carboxylic acid | HCID 6455317 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 7-Methylsulfamoyl-1,4-benzodioxane-5-carbonyl chloride | HCID 20544720 | — |
Reaction Steps
176.5 g of thionyl chloride were introduced into a balloon flask provided with a condenser. Then, in portions, 135 g of 7-methylsulfamoyl-1,4-benzodioxane-5-carboxylic acid were added under heating at 40°-45° C. The mixture was heated under reflux and then treated with 250 cm3 chloroform. The precipitate was dried off and washed with chloroform.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04248885 |
| Source dataset | uspto-grants-1981_02 |
| ORD ID | ord-a10e87002b2249df8567e7a151277391 |
| Source note | uspto-grants-1981_02 |