Ethyl sulfate anion → 7-Ethylthio-1,4-benzodioxane-5-carboxylic acid

HRID 1413139노트

반응식

HRID 1413139 반응식
[SH:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=[O:13])[C:5]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[CH:11]=1.[CH2:15](OS([O-])(=O)=O)[CH3:16]>O>[CH2:15]([S:1][C:2]1[CH:3]=[C:4]([C:12]([OH:14])=[O:13])[C:5]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[CH:11]=1)[CH3:16]

참가 물질

4

반응물 2

HCID 3804841Ethyl sulfate anionHCID 205446947-Mercapto-1,4-benzodioxane-5-carboxylic acid

생성물 1

HCID 205447267-Ethylthio-1,4-benzodioxane-5-carboxylic acid수율 81%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

166 g of 7-mercapto-1,4-benzodioxane-5-carboxylic acid, 242 cm3 of water, 216 cm3 of soda lye and 181 g of ethylsulfate were introduced into a balloon flask provided with a condenser. The mixture was heated under reflux and then cooled. The solution was poured into 1.3 l of water, filtered and treated with 110 cm3 of hydrochloric acid. The precipitate was dried off, washed with water and dried. 152 g of 7-ethylthio-1,4-benzodioxane-5-carboxylic acid were obtained (M.P.: 153°-154° C.; yield: 81%).

후처리

  1. customprovided with a condenser
  2. temperatureThe mixture was heated
  3. temperatureunder reflux
  4. temperaturecooled
  5. filtrationfiltered
  6. additiontreated with 110 cm3 of hydrochloric acid
  7. customThe precipitate was dried off
  8. washwashed with water
  9. customdried

출처 및 근거

ORD 기록
ord-8d7843cb553b42ab94351e75ac0ee27a
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04248885

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