Ammonia → 8-Methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid

HRID 1413167노트

반응식

HRID 1413167 반응식
[NH3:1].[CH3:2][O:3][C:4]1[C:9]2[O:10][CH2:11][CH2:12][O:13][C:8]=2[C:7]([C:14]([OH:16])=[O:15])=[CH:6][C:5]=1[S:17](Cl)(=[O:19])=[O:18]>O>[CH3:2][O:3][C:4]1[C:9]2[O:10][CH2:11][CH2:12][O:13][C:8]=2[C:7]([C:14]([OH:16])=[O:15])=[CH:6][C:5]=1[S:17](=[O:19])(=[O:18])[NH2:1]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 205447488-Methoxy-7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid

생성물 1

HCID 205446908-Methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid수율 82%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

300 g of 34% ammonia were introduced into a balloon flask provided with an agitator and a thermometer and then 159 g of 8-methoxy-7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid were added in portions, the temperature being maintained at from 0°-5° C. The mixture was agitated and then the precipitate was dissolved in water. The solution was filtered and treated with 280 cm3 of concentrated hydrochloric acid. The precipitate was dried off, washed and dried. 118 g of 8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid were obtained (M.P.: 247°-248° C.; yield: 82%).

후처리

  1. customprovided with an agitator
  2. temperaturethe temperature being maintained at from 0°-5° C
  3. filtrationThe solution was filtered
  4. additiontreated with 280 cm3 of concentrated hydrochloric acid
  5. customThe precipitate was dried off
  6. washwashed
  7. customdried

출처 및 근거

ORD 기록
ord-bcb23e05cc7a4c4e9defcb61d9f5df00
출처 데이터셋
uspto-grants-1981_02
특허 번호
US04248885

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