反应详情

温度

150 °C

In 20.8 ml of pyridine were dissolved 5.2 g (40 m mol) of 5-fluorouracil and 14 g (200 m mol) of 2,3-dihydrofuran. The solution were heated at about 150° C. in a closed tubular reactor under agitation for 6 hours. After the reaction, the reaction mixture was concentrated to dryness under reduced pressure. The residue was dissolved in chloroform and the solution was passed through a column of silica gel. The column was eluated with chloroform and the effluent was concentrated to dryness under reduced pressure. The residue was washed with a small amount of petroleum ether to give the above-mentioned compound as colorless crystals.

1. customAfter the reaction
2. concentrationthe reaction mixture was concentrated to dryness under reduced pressure
3. dissolutionThe residue was dissolved in chloroform
4. concentrationthe effluent was concentrated to dryness under reduced pressure
5. washThe residue was washed with a small amount of petroleum ether