Acetone → HCID 12540258, compound

HRID 1413233Notes

Reaction equation

HRID 1413233 reaction equation
[F:1][C:2]([F:8])([F:7])[S:3](Cl)(=[O:5])=[O:4].[Cl:9][C:10]1[C:18]([Cl:19])=[C:17]2[C:13]([CH2:14][C:15]([CH3:27])([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:16]2=[O:20])=[CH:12][C:11]=1CC(O)=O.CC(C)=[O:34]>>[Cl:9][C:10]1[C:18]([Cl:19])=[C:17]2[C:13]([CH2:14][C:15]([CH3:27])([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:16]2=[O:20])=[CH:12][C:11]=1[O:4][S:3]([C:2]([F:8])([F:7])[F:1])(=[O:34])=[O:5]

Participants

4

Reactant 3

HCID 180AcetoneHCID 79000Trifluoromethanesulfonyl chlorideHCID 12540266HCID 12540266, compound

Product 1

HCID 12540258HCID 12540258, compound

Procedure

After ten minutes a solution of trifluoromethanesulfonyl chloride (11.84 g., 0.07 mole) in acetone (150 ml.) is added over 10 minutes. After 15 minutes of stirring the precipitated salts are filtered and the acetone is evaporated at reduced pressure to leave an oil which upon trituration with hexane gives 15 g. of (6,7-dichloro-1-oxo-2-methyl-2-phenyl-5-indanyl)acetic acid which melts at 105°-107° C.

Workup

  1. filtrationare filtered
  2. customthe acetone is evaporated at reduced pressure
  3. customto leave an oil which upon trituration with hexane
  4. customgives 15 g

Sources & evidence

ORD record
ord-e3d5edf3e5e14a1796170587c99d4663
Source dataset
uspto-grants-1981_02
Patent number
US04249021

Reaction notes

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