HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 5-Methyl-2-phenyl-1H-imidazole-4-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | 1H-Imidazole-4-methanol, 5-methyl-2-phenyl- | HCID 83658 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 5-Methyl-2-phenyl-1H-imidazole-4-carbaldehyde | HCID 13548649 | — |
Reaction Steps
A 102.1 gm. portion of 5-methyl-2-phenyl-4-imidazolemethanol is dissolved in 765 ml. of concentrated HNO3. The solution is cooled in an ice bath and allowed to stand for 16 hours. The solution is heated on a steam bath for 30 minutes, diluted with 2.3 liters of water and neutralized with 50% NaOH while cooling in an ice bath. The solid is collected, dried, recrystallized from 200 ml. of ethanol and then from 1 liter of 1:2 ethanol:water giving the desired product, m.p. 102°14 115° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE030511 |
| Source dataset | uspto-grants-1981_02 |
| ORD ID | ord-3ec550555756455b9a1c25da691c8198 |
| Source note | uspto-grants-1981_02 |