Trimethylamine → HCID 20291468, compound

HRID 1413311Notes

Reaction equation

HRID 1413311 reaction equation
[CH3:1][C:2]1([CH3:15])[NH:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[O:3]1.[Cl:16][C:17]([Cl:22])([Cl:21])[C:18](Cl)=[O:19].CN(C)C>C1C=CC=CC=1>[CH3:1][C:2]1([CH3:15])[N:6]([C:18](=[O:19])[C:17]([Cl:22])([Cl:21])[Cl:16])[CH2:5][CH:4]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[O:3]1

Participants

5

Reactant 3

HCID 1146TrimethylamineHCID 6420Trichloroacetyl chlorideHCID 20291473HCID 20291473, compound

Product 1

HCID 20291468HCID 20291468, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To 24.8 milliliters of 25 percent w/v, 2,2-dimethyl-5-phenoxymethyl oxazolidine in 50 milliliters of benzene was added 5.5 grams of trichloroacetyl chloride. To this solution was added dropwise with cooling 3.1 grams of trimethylamine. After work-up with water, drying and removal of the benzene in vacuo, there was obtained 8.1 grams of the title compound, nD30 1.5272. Analytical data supports the structure.

Workup

  1. additionTo this solution was added dropwise
  2. dry with materialAfter work-up with water, drying
  3. customremoval of the benzene in vacuo

Sources & evidence

ORD record
ord-d95d4be500f84e7bb8de29505c23d340
Source dataset
uspto-grants-1981_02
Patent number
US04249932

Reaction notes

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