HCID 13046999, compound → 8-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine

HRID 1413335Notes

Reaction equation

HRID 1413335 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH2:12][N+:13]([O-])=[CH:14][CH:10]3[CH2:9][N:8]=[C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])[C:6]=2[CH:23]=1.CC(C)([O-])C.[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][CH:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])[C:6]=2[CH:23]=1

Participants

4

Reactant 2

HCID 13046999HCID 13046999, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 1859468-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 50 mg of 8-chloro-6-(2-fluorophenyl)-3a,4-dihydro-1H-imidazo[1,5-a][1,4]benzodiazepine 2-oxide in 3 ml of ethanol contianing 25 mg of potassium t-butoxide was heated to reflux for 10 min. The mixture was evaporated partially and the residue was partitioned between methylene chloride and sodium bicarbonate solution. The organic phase was dried and evaporated. Crystallization of the residue from ether yielded product with mp 148°-151° C.

Workup

  1. temperatureto reflux for 10 min
  2. customThe mixture was evaporated partially
  3. customthe residue was partitioned between methylene chloride and sodium bicarbonate solution
  4. customThe organic phase was dried
  5. customevaporated
  6. customCrystallization of the residue from ether yielded product with mp 148°-151° C.

Sources & evidence

ORD record
ord-e8f26de05c1c49a3be1c35a3afbcea98
Source dataset
uspto-grants-1981_02
Patent number
US04250095

Reaction notes

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