HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetic Acid → 8-chloro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetic Acid | HCID 300 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 7-Chloro-5-(2-chlorophenyl)-2-hydrazinyl-3H-1,4-benzodiazepine | HCID 12390875 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 8-chloro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine | HCID 12612348 | — |
Reaction Steps
In the manner given in Preparation 5, 7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl hydrazine (31.9 g., 0.1 mole) was reacted with chloroacetyl chloride (11.3 g. 0.1 mole) the resulting chloroacetic acid, 2-(7-chloro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl)hydrozide was cyclized in hot acetic acid to give 8-chloro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine. The analytical sample had a melting point of 195°-198° C. with decomposition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04250094 |
| Source dataset | uspto-grants-1981_02 |
| ORD ID | ord-78c8d87836054df19db2e781bab536fd |
| Source note | uspto-grants-1981_02 |