HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetyl bromide → 8-nitro-1(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 7-nitro-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine | HCID 20291856 | — |
| Product | 8-nitro-1(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine | HCID 20291832 | — |
Reaction Steps
In the manner given in Preparation 2, 7-nitro-5-(o-chlorophenyl)-3H-1,4-benzodiazepin-2-yl hydrazine was reacted with bromoacetyl bromide and after 1.5 hours with sodium acetate, then refluxed to give 8-nitro-1-(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04250094 |
| Source dataset | uspto-grants-1981_02 |
| ORD ID | ord-d5f4a185bd6146cdb761fd5de0a1c109 |
| Source note | uspto-grants-1981_02 |