Dipropylamine → 8-chloro-1-[(diethyl amino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

HRID 1413365Notes

Reaction equation

HRID 1413365 reaction equation
[C:1]1([C:7]2C3C=CC=CC=3N3C=NN=[C:10]3[CH2:9][N:8]=2)C=CC=CC=1.C(NCCC)CC.[Cl:28][C:29]1[CH:30]=[CH:31][C:32]2[N:38]3[C:39]([CH2:42]Cl)=[N:40][N:41]=[C:37]3[CH2:36][N:35]=[C:34]([C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)[C:33]=2[CH:50]=1>>[Cl:28][C:29]1[CH:30]=[CH:31][C:32]2[N:38]3[C:39]([CH2:42][N:8]([CH2:9][CH3:10])[CH2:7][CH3:1])=[N:40][N:41]=[C:37]3[CH2:36][N:35]=[C:34]([C:44]3[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=3)[C:33]=2[CH:50]=1

Participants

4

Reactant 3

HCID 8902DipropylamineHCID 125625186-phenyl-4H-s-triazolo[4,3-a][1,4-]benzodiazepineHCID 126123458-chloro-1-(chloromethyl)-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 126123578-chloro-1-[(diethyl amino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Procedure

In the manner given in Example 4, 8-chloro-1-[di-propylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepine is prepared by reacting dipropylamine with 8-chloro-1-(chloromethyl)-6-phenyl-4H-s-triazolo[4,3-a]-[1,4]-benzodiazepine.

Workup

  1. customis prepared

Sources & evidence

ORD record
ord-75be1814d95b42a3ad2d6cbd30f15107
Source dataset
uspto-grants-1981_02
Patent number
US04250094

Reaction notes

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