HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → Mono-N-demethyladinazolam
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 8-chloro-1-(chloromethyl)-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine | HCID 12612345 | — |
| Product | Mono-N-demethyladinazolam | HCID 119094 | — |
Reaction Steps
In the manner given in Example 1, 8-chloro-1-(chloromethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine was reacted with methylamine in the presence of sodium iodide to give 8-chloro-1-[(methylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepin of melting point 152°-156° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04250094 |
| Source dataset | uspto-grants-1981_02 |
| ORD ID | ord-ea33c69988da43118d0825464d03cbf4 |
| Source note | uspto-grants-1981_02 |