Benzylamine → HCID 86737473, compound

HRID 1413392Notes

Reaction equation

C(N)C1C=CC=CC=1.C(O[C:17]([N:19]([CH2:21][C:22]([NH:24][C@H:25]([C:27]([NH:29][C@H:30]([C:33]([NH:35][C@H:36]([P:38](=[O:41])([OH:40])[OH:39])[CH3:37])=[O:34])[CH2:31][OH:32])=[O:28])[CH3:26])=[O:23])C)=O)C1C=CC=CC=1>>[NH:19]([CH2:21][C:22]([NH:24][C@H:25]([C:27]([NH:29][C@H:30]([C:33]([NH:35][C@H:36]([P:38](=[O:39])([OH:41])[OH:40])[CH3:37])=[O:34])[CH2:31][OH:32])=[O:28])[CH3:26])=[O:23])[CH3:17]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 53749133HCID 53749133, compound

Product 1

HCID 86737473HCID 86737473, compound

Procedure

In a manner analogous to that described in Example 3(ii), from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-sarcosyl-L-alanyl-L-seryl)amino]-ethylphosphonic acid there was obtained (1R)-1-(N-sarcosyl-L-alanyl-L-serylamino)-ethylphosphonic acid of melting point 259°-260° C. (decomposition); [α]D20 =-92.3° (c=0.5% in water).

Sources & evidence

ORD record: ord-4d435587f58b40b9addb629f8e0e18e6
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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