Benzylamine → HCID 53787576, compound

HRID 1413393Notes

Reaction equation

C(N)C1C=CC=CC=1.C(OC([NH:19][C@H:20]([C:22]([NH:24][C@H:25]([C:29]([NH:31][C@H:32]([P:34](=[O:37])([OH:36])[OH:35])[CH3:33])=[O:30])[CH2:26][CH2:27][CH3:28])=[O:23])[CH3:21])=O)C1C=CC=CC=1>>[NH2:19][C@H:20]([C:22]([NH:24][C@H:25]([C:29]([NH:31][C@H:32]([P:34](=[O:35])([OH:37])[OH:36])[CH3:33])=[O:30])[CH2:26][CH2:27][CH3:28])=[O:23])[CH3:21]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 54143168HCID 54143168, compound

Product 1

HCID 53787576HCID 53787576, compound

Procedure

In a manner analogous to that described in Example 5(A)(iii), from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-L-alanyl-L-norvalyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(L-alanyl-L-norvalylamino)-ethylphosphonic acid of melting point 268°-270° C.; [α]D20 =-50.4°; [α]36520 =-201° (c=0.46%, a freshly prepared solution in 1-N sodium hydroxide).

Sources & evidence

ORD record: ord-f353c9986fb44a38a2f5d08d18b8b773
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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