Benzylamine → HCID 86737474, compound

HRID 1413394Notes

Reaction equation

C(N)C1C=CC=CC=1.C(O[C:17]([N:19]([CH2:21][C:22]([NH:24][C@H:25]([C:27]([NH:29][C@H:30]([C:34]([NH:36][C@H:37]([P:39](=[O:42])([OH:41])[OH:40])[CH3:38])=[O:35])[CH2:31][CH2:32][CH3:33])=[O:28])[CH3:26])=[O:23])C)=O)C1C=CC=CC=1>>[NH:19]([CH2:21][C:22]([NH:24][C@H:25]([C:27]([NH:29][C@H:30]([C:34]([NH:36][C@H:37]([P:39](=[O:40])([OH:42])[OH:41])[CH3:38])=[O:35])[CH2:31][CH2:32][CH3:33])=[O:28])[CH3:26])=[O:23])[CH3:17]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 70558145HCID 70558145, compound

Product 1

HCID 86737474HCID 86737474, compound

Procedure

In a manner analogous to that described in Example 5(A)(iii), from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-sarcosyl-L-alanyl-L-norvalyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(N-sarcosyl-L-alanyl-L-norvalylamino)-ethylphosphonic acid of melting point 291°-292° C. (decomposition); [α]D20 =-110°; [α]36520 =-391° (c=0.26% in water).

Sources & evidence

ORD record: ord-a8b189ed17ac4e68a7220ad6bb147d97
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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