Benzylamine → HCID 53658936, compound

HRID 1413395Notes

Reaction equation

C(N)C1C=CC=CC=1.C(OC([NH:19][C@H:20]([C:23]([NH:25][C@H:26]([C:28]([NH:30][C@H:31]([P:33](=[O:36])([OH:35])[OH:34])[CH3:32])=[O:29])[CH3:27])=[O:24])[CH2:21][OH:22])=O)C1C=CC=CC=1>>[NH2:19][C@H:20]([C:23]([NH:25][C@H:26]([C:28]([NH:30][C@H:31]([P:33](=[O:34])([OH:36])[OH:35])[CH3:32])=[O:29])[CH3:27])=[O:24])[CH2:21][OH:22]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 54210728HCID 54210728, compound

Product 1

HCID 53658936HCID 53658936, compound

Procedure

In a manner analogous to that described in Example 3(ii) from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-L-seryl-L-alanyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(L-seryl-L-alanylamino)-ethylphosphonic acid of melting point 256°-257° C. (decomposition); [α]D20 =-61.4°; [α]36520 =-222° (c=0.5% in water).

Sources & evidence

ORD record: ord-d6d379cbb40242c6a1637b8b28143d45
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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