Benzylamine → HCID 54429596, compound

HRID 1413397Notes

Reaction equation

C(N)C1C=CC=CC=1.C(OC([NH:19][C@H:20]([C:24]([NH:26][C@H:27]([C:29]([NH:31][C@H:32]([P:34](=[O:37])([OH:36])[OH:35])[CH3:33])=[O:30])[CH3:28])=[O:25])[CH2:21][CH2:22][CH3:23])=O)C1C=CC=CC=1>>[NH2:19][C@H:20]([C:24]([NH:26][C@H:27]([C:29]([NH:31][C@H:32]([P:34](=[O:35])([OH:37])[OH:36])[CH3:33])=[O:30])[CH3:28])=[O:25])[CH2:21][CH2:22][CH3:23]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 54429264HCID 54429264, compound

Product 1

HCID 54429596HCID 54429596, compound

Procedure

In a manner analogous to that described in Example 5(A)(iii), from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-L-norvalyl-L-alanyl)amino]-ethyl-phosphonic acid there was obtained (1R)-1-(L-norvalyl-L-alanylamino)ethylphosphonic acid of melting point 260°-261° C. (decomposition); [α]D20 =-46.5°; [α]36520 =-168° (c=0.51% in water).

Sources & evidence

ORD record: ord-682d1b09b6744fab825360abd1f3a442
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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