Benzylamine → HCID 86737476, compound

HRID 1413398Notes

Reaction equation

C(N)C1C=CC=CC=1.C(O[C:17]([N:19]([CH2:21][C:22]([NH:24][C@H:25]([C:29]([NH:31][C@H:32]([C:34]([NH:36][C@H:37]([P:39](=[O:42])([OH:41])[OH:40])[CH3:38])=[O:35])[CH3:33])=[O:30])[CH2:26][CH2:27][CH3:28])=[O:23])C)=O)C1C=CC=CC=1>>[NH:19]([CH2:21][C:22]([NH:24][C@H:25]([C:29]([NH:31][C@H:32]([C:34]([NH:36][C@H:37]([P:39](=[O:40])([OH:42])[OH:41])[CH3:38])=[O:35])[CH3:33])=[O:30])[CH2:26][CH2:27][CH3:28])=[O:23])[CH3:17]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 54343677HCID 54343677, compound

Product 1

HCID 86737476HCID 86737476, compound

Procedure

In a manner analogous to that described in Example 5(A)(iii), from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-sarcosyl-L-norvalyl-L-alanyl)-amino]-ethylphosphonic acid there was obtained (1R)-1-(N-sarcosyl-L-norvalyl-L-alanylamino)-ethylphosphonic acid of melting point 277°-279° C. (decomposition); [α]D20 =-96.0°; [α]36520 =-348° (c=0.51% in water).

Sources & evidence

ORD record: ord-f326defcd9eb40168cb2863d64200ac0
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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