Benzylamine → HCID 54498075, compound

HRID 1413399Notes

Reaction equation

C(N)C1C=CC=CC=1.C(OC([NH:19][C@H:20]([C:24]([NH:26][C@H:27]([C:31]([NH:33][C@H:34]([P:36](=[O:39])([OH:38])[OH:37])[CH3:35])=[O:32])[CH2:28][CH2:29][CH3:30])=[O:25])[CH2:21][CH2:22][CH3:23])=O)C1C=CC=CC=1>>[NH2:19][C@H:20]([C:24]([NH:26][C@H:27]([C:31]([NH:33][C@H:34]([P:36](=[O:37])([OH:39])[OH:38])[CH3:35])=[O:32])[CH2:28][CH2:29][CH3:30])=[O:25])[CH2:21][CH2:22][CH3:23]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 54126620HCID 54126620, compound

Product 1

HCID 54498075HCID 54498075, compound

Procedure

In a manner analogous to that described in Example 5(A)(iii), from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-L-norvalyl-L-norvalyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(L-norvalyl-L-norvalylamino)-ethylphosphonic acid of melting point 273°-275° C. (decomposition); [α]D20 =-36.0°; [α]36520 =-153°, (c=0.5% freshly prepared in 0.1-N sodium hydroxide).

Sources & evidence

ORD record: ord-ee81d54f317349ce89046df4eea8ad8b
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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