Benzylamine → HCID 54015047, compound

HRID 1413400Notes

Reaction equation

C(N)C1C=CC=CC=1.C(OC([NH:19][CH2:20][C:21]([NH:23][C@H:24]([C:28]([NH:30][C@H:31]([P:33](=[O:36])([OH:35])[OH:34])[CH3:32])=[O:29])[CH2:25][CH2:26][CH3:27])=[O:22])=O)C1C=CC=CC=1>>[NH2:19][CH2:20][C:21]([NH:23][C@H:24]([C:28]([NH:30][C@H:31]([P:33](=[O:34])([OH:36])[OH:35])[CH3:32])=[O:29])[CH2:25][CH2:26][CH3:27])=[O:22]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 53755872HCID 53755872, compound

Product 1

HCID 54015047HCID 54015047, compound

Procedure

In a manner analogous to that described in Example 5(A)(iii), from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-glycyl-L-norvalyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(glycyl-L-norvalylamino)-ethylphosphonic acid of melting point 265°-267° C. (decomposition); [α]D20 =-74.2°; [α]36520 =-271° (c=0.49% in water).

Sources & evidence

ORD record: ord-4a22971506c14d56baf9560568a33fff
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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