Benzylamine → HCID 22814546, compound

HRID 1413401Notes

Reaction equation

C(N)C1C=CC=CC=1.C(O[C:17]([N:19]([CH2:21][C:22]([NH:24][CH2:25][C:26]([NH:28][C@H:29]([C:33]([NH:35][C@H:36]([P:38](=[O:41])([OH:40])[OH:39])[CH3:37])=[O:34])[CH2:30][CH2:31][CH3:32])=[O:27])=[O:23])C)=O)C1C=CC=CC=1>>[NH:19]([CH2:21][C:22]([NH:24][CH2:25][C:26]([NH:28][C@H:29]([C:33]([NH:35][C@H:36]([P:38](=[O:39])([OH:41])[OH:40])[CH3:37])=[O:34])[CH2:30][CH2:31][CH3:32])=[O:27])=[O:23])[CH3:17]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 53965384HCID 53965384, compound

Product 1

HCID 22814546HCID 22814546, compound

Procedure

In a manner analogous to that described in Example 5(A)(iii), from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-sarcosyl-glycyl-L-norvalyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(N-sarcosyl-glycyl-L-norvalylamino)-ethylphosphonic acid of melting point 255°-257° C. (decomposition); [α]D20 =-64.2°; [α]36520 =-235° (c=0.49% in water).

Sources & evidence

ORD record: ord-8602509844994a4191fe5d8b4005db85
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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