Benzylamine → HCID 86737478, compound

HRID 1413403Notes

Reaction equation

C(N)C1C=CC=CC=1.[CH2:9]([N:12](C(OCC1C=CC=CC=1)=O)[CH2:13][C:14]([NH:16][C@H:17]([C:19]([NH:21][C@H:22]([C:24]([NH:26][C@H:27]([P:29](=[O:32])([OH:31])[OH:30])[CH3:28])=[O:25])[CH3:23])=[O:20])[CH3:18])=[O:15])[CH:10]=[CH2:11]>>[CH2:9]([NH:12][CH2:13][C:14]([NH:16][C@H:17]([C:19]([NH:21][C@H:22]([C:24]([NH:26][C@H:27]([P:29](=[O:30])([OH:32])[OH:31])[CH3:28])=[O:25])[CH3:23])=[O:20])[CH3:18])=[O:15])[CH:10]=[CH2:11]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 54234971HCID 54234971, compound

Product 1

HCID 86737478HCID 86737478, compound

Procedure

In a manner analogous to that described in Example 7 (A)(ii), from the monobenzylamine salt of (1R)-1-[(N-allyl-N-benzyloxycarbonyl-glycyl-L-alanyl-L-alanyl)amino]-ethylphosphonic acid [prepared as described in Example 20(B)(i)] there was obtained (1R)-1-(N-allyl-glycyl-L-alanyl-L-alanylamino)-ethylphosphonic acid of melting point 251°-253° C. (decomposition); [α]D20 =-110°; [α]36520 =-394° (c=1% in water).

Sources & evidence

ORD record: ord-4aa76388122e4361b3163fe5c38a59aa
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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