Benzylamine → HCID 86737480, compound

HRID 1413405Notes

Reaction equation

C(N)C1C=CC=CC=1.C(O[C:17]([N:19]([CH2:21][C:22]([NH:24][C@H:25]([C:27]([NH:29][C@H:30]([P:32](=[O:35])([OH:34])[OH:33])[CH3:31])=[O:28])[CH3:26])=[O:23])C)=O)C1C=CC=CC=1>>[NH:19]([CH2:21][C:22]([NH:24][C@H:25]([C:27]([NH:29][C@H:30]([P:32](=[O:33])([OH:35])[OH:34])[CH3:31])=[O:28])[CH3:26])=[O:23])[CH3:17]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 53849204HCID 53849204, compound

Product 1

HCID 86737480HCID 86737480, compound

Procedure

In a manner analogous to that described in Example 1(B)(ii), from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-sarcosyl-L-alanyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(N-sarcosyl-L-alanylamino)-ethylphosphonic acid of melting point 245°-246° C. (decomposition); [α]D20 =-84.2°; [α]36520 =-312° (c=0.5% in water).

Sources & evidence

ORD record: ord-ed4adf30d1d8420888fed591ff6d1eaf
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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