Benzylamine → HCID 86737481, compound

HRID 1413406Notes

Reaction equation

C(N)C1C=CC=CC=1.C(O[C:17]([N:19](C)[C@H:20]([C:24]([NH:26][C@H:27]([C:31]([NH:33][C@H:34]([P:36](=[O:39])([OH:38])[OH:37])[CH3:35])=[O:32])[CH2:28][CH2:29][CH3:30])=[O:25])[CH2:21][CH2:22][CH3:23])=O)C1C=CC=CC=1>>[CH3:17][NH:19][C@H:20]([C:24]([NH:26][C@H:27]([C:31]([NH:33][C@H:34]([P:36](=[O:37])([OH:39])[OH:38])[CH3:35])=[O:32])[CH2:28][CH2:29][CH3:30])=[O:25])[CH2:21][CH2:22][CH3:23]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 53911737HCID 53911737, compound

Product 1

HCID 86737481HCID 86737481, compound

Procedure

In a manner analogous to that described in Example 7(A)(ii) from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-N-methyl-L-norvalyl-L-norvalyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(N-methyl-L-norvalyl-L-norvalylamino)-ethylphosphonic acid of melting point 294°-295° C. (decomposition); [α]D20 =-52.6°; [α]36520 =-190° (c=0.5%, freshly prepared in 0.1-N sodium hydroxide).

Sources & evidence

ORD record: ord-f2c2a2ef60844db1948e59273e8ae170
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

Loading…