Benzylamine → HCID 86737484, compound

HRID 1413409Notes

Reaction equation

C(N)C1C=CC=CC=1.C(O[C:17]([N:19](C)[C@H:20]([C:24]([NH:26][C@H:27]([C:31]([NH:33][C@H:34]([C:38]([NH:40][C@H:41]([P:43](=[O:46])([OH:45])[OH:44])[CH3:42])=[O:39])[CH2:35][CH2:36][CH3:37])=[O:32])[CH2:28][CH2:29][CH3:30])=[O:25])[CH:21]([CH3:23])[CH3:22])=O)C1C=CC=CC=1>>[CH3:17][NH:19][C@H:20]([C:24]([NH:26][C@H:27]([C:31]([NH:33][C@H:34]([C:38]([NH:40][C@H:41]([P:43](=[O:44])([OH:46])[OH:45])[CH3:42])=[O:39])[CH2:35][CH2:36][CH3:37])=[O:32])[CH2:28][CH2:29][CH3:30])=[O:25])[CH:21]([CH3:22])[CH3:23]

Participants

Reactant 2

HCID 7504Benzylamine

HCID 53711826HCID 53711826, compound

Product 1

HCID 86737484HCID 86737484, compound

Procedure

In a manner analogous to that described in Example 5(A) (iii), from the monobenzylamine salt of (1R)-1-[(N-benzyloxycarbonyl-N-methyl-L-valyl-L-norvalyl-L-norvalyl)amino]-ethylphosphonic acid there was obtained (1R)-1-(N-methyl-L-valyl-L-norvalyl-L-norvalylamino)-ethylphosphonic acid of melting point 300°-302° C. (decomposition).

Sources & evidence

ORD record: ord-772e077cde354198a6b1caeaea92cca0
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250085

Reaction notes

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