HCID 54326340, compound → HCID 54143976, compound

HRID 1413412Notes

Reaction equation

HRID 1413412 reaction equation
C(OC([NH:11][C@H:12]([C:14]([NH:16][C@H:17]([C:19]([NH:21][C@H:22]([P:24](=[O:29])([O:27][CH3:28])[O:25][CH3:26])[CH3:23])=[O:20])[CH3:18])=[O:15])[CH3:13])=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C@H:12]([C:14]([NH:16][C@H:17]([C:19]([NH:21][C@H:22]([P:24](=[O:29])([O:25][CH3:26])[O:27][CH3:28])[CH3:23])=[O:20])[CH3:18])=[O:15])[CH3:13]

Participants

4

Reactant 1

HCID 54326340HCID 54326340, compound

Product 1

HCID 54143976HCID 54143976, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 23938PalladiumSolvent

Procedure

Dimethyl (1R)-1-[(N-benzyloxycarbonyl-L-alanyl-L-alanyl)amino]-ethylphosphonate was dissolved in methanol and catalytically hydrogenated in the presence of 10% palladium-on-charcoal. The solution was filtered and evaporated to give dimethyl (1R)-1-(L-alanyl-L-alanylamino)-ethylphosphonate in the form of an oil.

Workup

  1. filtrationThe solution was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-ca6daaa3343344b586dc48afb89e97e8
Source dataset
uspto-grants-1981_02
Patent number
US04250085

Reaction notes

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