Acetic Anhydride → 3-Acetyl-2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine

HRID 1413433Notes

Reaction equation

[CH3:1][O:2][C:3]([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([S:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:10][N:9]2[CH:21]=1)=[O:4].[C:22](OC(=O)C)(=[O:24])[CH3:23]>>[C:22]([C:21]1[N:9]2[CH:10]=[C:11]([S:14][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:12]=[CH:13][C:8]2=[N:7][C:6]=1[NH:5][C:3]([O:2][CH3:1])=[O:4])(=[O:24])[CH3:23]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 12414300Methyl [6-(phenylsulfanyl)imidazo[1,2-a]pyridin-2-yl]carbamate

Product 1

HCID 541486803-Acetyl-2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine

Procedure

A suspension of 2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine (500 mg.) in 10 ml. of acetic anhydride is treated as in Example 7 to yield 3-acetyl-2-(methoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine.

Sources & evidence

ORD record: ord-4a4501c66f8740fb80869618ef25ba87
Source dataset: uspto-grants-1981_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04250174

Reaction notes

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