Phosphorus pentachloride → HCID 12901645, compound

HRID 1413438Notes

Reaction equation

HRID 1413438 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10]([OH:12])=O)=[CH:4][N:3]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:14]>C(OCC)C>[ClH:14].[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:10]([Cl:14])=[O:12])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 24819Phosphorus pentachlorideHCID 128289592-Amino-4-methoxypyrimidine-5-carboxylic acid

Product 1

HCID 12901645HCID 12901645, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 16.9 g of 2-amino 4-methoxy 5-pyrimidinyl carboxylic acid prepared in stage 2, in suspension in 300 ml of anhydrous ethyl ether, were added at 0° C., 20.8 g of phosphorous pentachloride while stirring. After returning to room temperature for 3 hours, the precipitate was separated by filtration, rinsed several times with 50 ml of absolute ethyl ether. The hydrochloride of the 2-amino 4-methoxy 5-chlorocarbonyl pyrimidine thus obtained was used in the raw state in the following stage.

Workup

  1. customthe precipitate was separated by filtration
  2. washrinsed several times with 50 ml of absolute ethyl ether

Sources & evidence

ORD record
ord-e5e9dcf3a4c2432699fbb661ca6a4b19
Source dataset
uspto-grants-1981_02
Patent number
US04250178

Reaction notes

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