反应详情

To a stirred mixture of 45 parts of 5-chloro-2-(phenylmethyl)-1H-benzimidazole-1-propanol and 225 parts of trichloromethane are added dropwise 29.75 parts of sulfinyl chloride. Upon completion, stirring is continued for 6 hours at reflux temperature. The reaction mixture is evaporated and the residue is taken up in water. The product is extracted with trichloromethane. The extract is dried, filtered and evaporated. The reisude is purified by columnchromatography over silica gel using a mixture of trichloromethane and methanol (98:2) as eluent. The pure fractions are collected and the eluent is evaporated, yielding 5-chloro-1-(3-chloropropyl)-2-(phenylmethyl)-1H-benzimidazole as a solid residue.

1. temperatureat reflux temperature
2. customThe reaction mixture is evaporated
3. extractionThe product is extracted with trichloromethane
4. customThe extract is dried
5. filtrationfiltered
6. customevaporated
7. customThe reisude is purified by columnchromatography over silica gel using
8. additiona mixture of trichloromethane and methanol (98:2) as eluent
9. customThe pure fractions are collected
10. customthe eluent is evaporated