Methyl iodide → HCID 20506295, compound

HRID 1413474Notes

Reaction equation

HRID 1413474 reaction equation
[SH:1][C:2]1[N:6]([CH2:7][CH2:8][CH2:9][OH:10])[C:5]2[CH:11]=[CH:12][CH:13]=[CH:14][C:4]=2[N:3]=1.I[CH3:16]>CO>[CH3:16][S:1][C:2]1[N:6]([CH2:7][CH2:8][CH2:9][OH:10])[C:5]2[CH:11]=[CH:12][CH:13]=[CH:14][C:4]=2[N:3]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178520824HCID 178520824, compound

Product 1

HCID 20506295HCID 20506295, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 20.8 parts of 2-mercapto-1H-benzimidazole-1-propanol, 15.62 parts of iodomethane and 120 parts of methanol is stirred overnight at room temperature. The reaction mixture is evaporated and the residue is dissolved in 500 parts of water. The solution is filtered over hyflo and the filtrate is alkalized with solid potassium hydroxide. The oily product is extracted with trichloromethane. The extract is dried, filtered and evaporated yielding 2-(methylthio)-1H-benzimidazole-1-propanol as a residue.

Workup

  1. customThe reaction mixture is evaporated
  2. dissolutionthe residue is dissolved in 500 parts of water
  3. filtrationThe solution is filtered over hyflo
  4. extractionThe oily product is extracted with trichloromethane
  5. customThe extract is dried
  6. filtrationfiltered
  7. customevaporated

Sources & evidence

ORD record
ord-3af562f79e3c48d5a9e1b427e85e73d6
Source dataset
uspto-grants-1981_02
Patent number
US04250176

Reaction notes

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