HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → N-(4,5-dichloro-2-nitrophenyl)-4-(diphenylmethyl)-1-piperazinepropanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Benzhydrylpiperazine | HCID 70048 | — |
| Reactant | 4,5-dichloro-N-(3-chloropropyl) 2-nitrobenzenamine | HCID 13105626 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | N-(4,5-dichloro-2-nitrophenyl)-4-(diphenylmethyl)-1-piperazinepropanamine | HCID 20506343 | — |
Reaction Steps
A mixture of 6.5 parts of 4,5-dichloro-N-(3-chloropropyl)-2-nitrobenzenamine, 5.6 parts of 1-(diphenylmethyl)piperazine, 5.3 parts of sodium carbonate, 0.1 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight. The reaction mixture is cooled to room temperature and water is added. The organic phase is separated, dried, filtered and evaporated, yielding N-(4,5-dichloro-2-nitrophenyl)-4-(diphenylmethyl)-1-piperazinepropanamine as a residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04250176 |
| Source dataset | uspto-grants-1981_02 |
| ORD ID | ord-7555b07df0ee4afc8f7dbf773ef68355 |
| Source note | uspto-grants-1981_02 |