関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,1'-(Bromomethylene)bis(4-fluorobenzene) | HCID 67665 | — |
| 反応物 | Ethyl 4-hydroxypiperidine-1-carboxylate | HCID 96394 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 20506316 | HCID 20506316 | — |
反応手順
A mixture of 21.5 parts of ethyl 4-hydroxy-1-piperadinecarboxylate, 35.2 parts of bis(4-fluorophenyl)bromomethane and 8.6 parts of potassium carbonate is stirred and heated in an oil-bath at 140° C. for 3 hours. The reaction mixture is allowed to cool to room temperature and water is added. The product is extracted with methylbenzene. The extract is washed successively with water, a diluted hydrochloric acid solution and a sodium bicarbonate solution, dried, filtered and evaporated. The forerun is distilled off (bp. till 143° C. at 0.5-1 mm. pressure), yielding ethyl 4-[bis(4-fluorophenyl)methoxy]-1-piperidinecarboxylate as an oily residue.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04250176 |
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| 出典データセット | uspto-grants-1981_02 |
|---|
| ORD ID | ord-edaeabc5330e4524a42fb61d6c312e3b |
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| 出典メモ | uspto-grants-1981_02 |
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