反应详情

To a stirred and cooled (10°-15° C.) mixture of 25 parts of (2,4-dichlorophenyl)(4-fluorophenyl)methanone and 80 parts of methanol are added portionwise 4.9 parts of sodium borohydride at about 10° C. Upon completion, stirring is continued overnight at room temperature. The reaction mixture is diluted with water and the solvent is evaporated. The residue is taken up in water and the product is extracted with trichloromethane. The extract is washed with water, dried, filtered and evaporated, yielding 22 parts of 2,4-dichloro-α-(4-fluorophenyl)benzenemethanol as a residue.

1. temperaturecooled
2. stirringUpon completion, stirring
3. customthe solvent is evaporated
4. extractionthe product is extracted with trichloromethane
5. washThe extract is washed with water
6. customdried
7. filtrationfiltered
8. customevaporated