Potassium Iodide → 1-[3-{4-[(2-chlorophenyl)phenylmethyl]-1-piperazinyl}propyl]1H-benzimidazole trihydrochloride dihydrate

Participants

Reaction Steps

A mixture of 4.9 parts of 1-(3-chloropropyl)-1H-benzimidazole, 7 parts of 1-[(2-chlorophenyl)phenylmethyl]piperazine acetate, 10.6 parts of sodium carbonate, 0.1 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 20 hours with water-separator. The reaction mixture is cooled, water is added and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is converted into the hydrochloride salt in 2-propanol and 2,2'-oxybispropane. The salt is filtered off and crystallized from 2-propanol, yielding 1-[3-{4-[(2-chlorophenyl)phenylmethyl]-1-piperazinyl}propyl]1H-benzimidazole trihydrochloride dihydrate; mp. 182.9° C.

Provenance & Evidence