Imidazole → 4-Trimethylsilylethynyl-1-octyn-4-ol trimethylsilyl ether

Participants

Reaction Steps

To a stirred mixture of 8.5 grams of 4-trimethylsilylethynyl-1-octyn-4-ol and 6.2 grams of imidazole in 24 ml of dry dimethylformamide is added, under nitrogen, 5.7 ml of chlorotrimethylsilane, in a slow stream, via a syringe. The mixture is stirred in an ice bath for one hour and then at room temperature overnight. The mixture is poured into hexane, washed with saturated sodium bicarbonate solution, water and then brine and dried over sodium sulfate. The solvents are evaporated to dryness yielding 11.1 grams of the desired product.

Provenance & Evidence