Butyric acid, 4-(p-chloro-N-2,6-xylylbenzamido)- → ethyl N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-(2,6-dimethylanilino)butyrate

Participants

Reaction Steps

Analogously to Example 1, using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyric acid and ethyl 4-(2,6-dimethylanilino)butyrate and suitable processing produces ethyl N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-(2,6-dimethylanilino)butyrate (M.P. 95° to 97°), the saponification of which and the processing of the reaction product yields N-[N-(p-chlorobenzoyl)-4-(2,6-dimethylanilino)butyryl]-4-(2,6-dimethylanilino)butyric acid (M.P. 129° to 131°).

Provenance & Evidence