Glycine ethyl ester → ethyl N-[N-(p-chlorobenzoyl)-4-(p-anisidino)butyryl]glycinate

HRID 1413603Notes

Reaction equation

HRID 1413603 reaction equation
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH2:17][CH2:18][CH2:19][C:20](O)=[O:21])[C:9]2[CH:16]=[CH:15][C:12]([O:13][CH3:14])=[CH:11][CH:10]=2)=[O:7])=[CH:4][CH:3]=1.[NH2:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28]>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([N:8]([CH2:17][CH2:18][CH2:19][C:20]([NH:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])=[O:21])[C:9]2[CH:16]=[CH:15][C:12]([O:13][CH3:14])=[CH:11][CH:10]=2)=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 12176Glycine ethyl esterHCID 35378Clanobutin

Product 1

HCID 20292115ethyl N-[N-(p-chlorobenzoyl)-4-(p-anisidino)butyryl]glycinate

Procedure

Analogously to Example 1, by using equivalent quantities, reacting N-(p-chlorobenzoyl)-4-(p-anisidino)butyric acid and ethyl glycinate and suitable processing produces ethyl N-[N-(p-chlorobenzoyl)-4-(p-anisidino)butyryl]glycinate (oil), saponification of which and processing of the reaction product yields N-[N-(p-chlorobenzoyl)-4-(p-anisidino)butyryl]glycine (viscous oil).

Sources & evidence

ORD record
ord-94ba98370ec14e93b213af5f3bd135da
Source dataset
uspto-grants-1981_02
Patent number
US04250183

Reaction notes

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